José M. Barral, MD, PhD
- Education and Training
MD, Escuela de Medicina Ignacio A. Santos, Instituto Tecnológico y de Estudios Superiores de Monterrey (ITESM)
PhD, Baylor College of Medicine, Department of Biochemistry and Molecular Biology
Post-Doctoral Fellow, Department of Cellular Biochemistry, Max Planck Institute for Biochemistry
Before joining Kaiser Permanente School of Medicine, Dr. José Barral served as tenured Professor and Vice Chair for Operations in the Department of Neuroscience, Cell Biology and Anatomy; Senior Associate Dean for Academic Affairs in the Graduate School of Biomedical Sciences; and Director of the MD-PhD Combined Degree Program at the University of Texas Medical Branch. As the School’s Chair of Foundational Science, Dr. Barral collaborates with the Clinical Science and Health Systems Science Departments to lead faculty members in developing and implementing our medical school curriculum, which incorporates concepts and skills from each of these three major disciplines. His commitment to education and research has been recognized by several awards and appointments, and his work has been published in many prestigious journals, including Nature, Science, and Cell.
- Prior Positions (selected)
- 2005-2012Assistant Professor, Tenure-TrackDepartment of Neuroscience and Cell Biology, University of Texas Medical Branch2012-2016Associate Professor, TenuredDepartment of Neuroscience and Cell Biology, University of Texas Medical Branch2013-2018Member, Academy of Master TeachersUniversity of Texas Medical Branch2014-2015Assistant Dean for Academic Affairs, Graduate School of Biomedical SciencesUniversity of Texas Medical Branch2015-2018Associate Dean for Academic Affairs, Graduate School of Biomedical SciencesUniversity of Texas Medical Branch2015-2018Vice-Chair for Operations, Department of Neuroscience, Cell Biology and AnatomyUniversity of Texas Medical Branch2016-2018Professor, Tenured, Department of Neuroscience, Cell Biology and AnatomyUniversity of Texas Medical Branch2017-2018Director ad interim, MD-PhD Combined Degree ProgramUniversity of Texas Medical Branch2018Senior Associate Dean for Academic Affairs, Graduate School of Biomedical SciencesUniversity of Texas Medical Branch2018MemberUniversity of Texas System Kenneth I. Shine, MD, Academy of Health Science Education2018Director, MD-PhD Combined Degree ProgramUniversity of Texas Medical Branch
- Honors and Awards (selected)
- 1996Prof. John J. Trentin Award for Scholastic ExcellenceBaylor College of Medicine, Houston, Texas2001Harold M. Weintraub Graduate Student Award for outstanding achievement during Graduate Studies in the Biological SciencesFred Hutchinson Cancer Research Center, Seattle, Washington2006Pew ScholarPew Scholars Program in the Biomedical Sciences, San Francisco, California2008Basil O’Connor ScholarMarch of Dimes Birth Defects Foundation, White Plains, New York2013-2017Jimmy Doyle Dickens Memorial Faculty AwardSchool of Medicine, UTMB (selected by students; regarded as "best teacher" award)2015The Dr. Leon Bromberg Professorship for Excellence in Teaching in Memory of Truman Graves Blocker, Jr., MDUniversity of Texas Medical Branch2017The Hiram and Gloria Arnold Endowed Professorship for Teaching ExcellenceUniversity of Texas Medical Branch2017The John Sealy Distinguished Chair for MD-PhD Combined Degree Studies in Honor of Dr. Truman G. BlockerUniversity of Texas Medical Branch2018MemberThe University of Texas System Kenneth I. Shine, MD Academy of Health Science Education
- Publications (selected)
Peer-reviewed research manuscripts
Barral, J.M.; Hutagalung, A.H.; Brinker, A.; Hartl, F.U. and Epstein, H.F. Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin. Science 295: 669-671 (2002).
Agashe, V.R.; Guha, S.; Chang, H.-C.; Genevaux, P.; Hayer-Hartl, M.; Stemp, M.; Georgopoulos, C.; Hartl, F.U. and Barral, J.M. Function of trigger factor and DnaK in multi-domain protein folding: Increase in yield at the expense of folding speed. Cell 117:199-209 (2004).
Hoppe, T.; Cassata, G.; Barral, J.M.; Springer, W.; Hutagalung, A.H.; Epstein, H.F. and Baumeister, R. Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans. Cell 118:337-349 (2004).
Kaiser, C.M.; Chang, H.C., Agashe, V.R.; Lakshmipathy, S.K., Etchells, S.; Hayer-Hartl, M.; Hartl, F.U. and Barral, J.M. Real time observation of Trigger factor function on translating ribosomes. Nature 444:455-460; (2006).
Siller, E.; DeZwaan, D.C.; Anderson, J.F.; Freeman, B.C. and Barral, J.M. Slowing bacterial translation speed enhances eukaryotic protein folding efficiency. J. Mol. Biol. 396:1310-1308 (2010).
Anderson, J.F.; Siller, E. and Barral, J.M. The neurodegenerative disease-related protein sacsin is a molecular chaperone. J. Mol. Biol. 411:870-880 (2011).
Spencer, P.S.; Siller, E.; Anderson, J.F. and Barral, J.M. Silent substitutions predictably alter translation elongation rates and protein folding efficiencies. J. Mol. Biol. 422:328-335 (2012).
Zhou, M.; Guo, J.; Cha, J.; Chae, M.; Chen, S.; Barral, J.M.; Sachs, M.S.; and Liu, Y. Non-optimal codon usage determines the expression, structure and function of a circadian clock protein. Nature 495:111–115 (2013).
Kim, S.J.; Yoon, J.S.; Shishido, H.; Yang, Z.; Rooney, L.; Barral, J.M. and Skach, W.R. Translational tuning optimizes nascent protein folding in cells. Science 348:444–448 (2015).
Educational publications, abstracts and presentations
Barral, J.M. and Buck, E. What, how and why is problem-based learning in medical education? ASBMB Today. 12:34-35 (2013).
Barral, J.M. and Buck, E. Integrating Basic Science and Clinical Teaching Using Problem Based Learning. International Association of Medical Science Educators (IAMSE) Meeting, Nashville, Tennessee, June 8, 2014.
Barral, J.M. and Rampy, A. PowerPoint-Based Assessment of Microscopic Anatomy Knowledge and Skills. International Association of Medical Science Educators (IAMSE) Meeting, San Diego, California, June 13-16, 2015.
Barral, J.M. and Niesel, D.W. Recalibrating Biomedical Science Education. Poster presentation. NIGMS Symposium on Catalyzing the Modernization of Graduate Education, National Institutes of Health, Bethesda, Maryland, April 11, 2016.
Peng, B.-H., Coggeshall, R.E. and Barral, J.M. Narrated Animated Videos for Self-Learning of Histology. Oral presentation (by Dr. Peng). International Association of Medical Science Educators (IAMSE) Meeting, Burlington, Vermont, June 10-13, 2017.
Barral, J.M., Niesel, D.W., Peek, K., Howrey, B.T. and Fowler, G.A. An Interactive Competency Approach to Career Exploration and IDP Implementation. Poster presentation. Future of Bioscience Graduate and Postdoctoral Training Conference, University of Colorado Denver-Anschutz Medical Campus, Denver, Colorado, June 8-10, 2017.
Aronson, J., Ainsworth, A., Morey, O., Barral, J., Perez, N., Rudnicki, A. Launch Ramp: An expanded prematriculation course to introduce competency based medical education. Poster presented at the 21st Annual International Association of Medical Science Educators Meeting, Burlington, Vermont, June 10-13, 2017.
Barral, J.M. Computer Graphics and Interactive Techniques: Unsolved Challenges in Healthcare Education. The Association for Computing Machinery Special Interest Group on Computer Graphics and Interactive Technology (SIGGRAPH), Vancouver, British Columbia, Canada, August 12-16, 2018.